Yes, Wellbutrin (bupropion) can cause insomnia.
Insomnia is one of the most commonly reported side effects, especially during the first few weeks of treatment. Wellbutrin is a norepinephrine-dopamine reuptake inhibitor (NDRI), which means it increases the activity of certain stimulating brain chemicals. This boost in energy and alertness can make it harder to fall asleep or stay asleep in some individuals.
Why Does Wellbutrin Cause Insomnia?
Wellbutrin is considered a more activating antidepressant compared to others like SSRIs. Its stimulating effect:
- Helps with fatigue and low motivation
- Can lead to restlessness, anxiety, and sleep disturbances, especially if taken too late in the day
The risk of insomnia may be higher with the extended-release (XL) or sustained-release (SR) forms if not timed properly.
Tips to Manage Insomnia While Taking Wellbutrin
- Take it in the morning. Taking Wellbutrin earlier in the day helps reduce its impact on your sleep.
- Avoid caffeine or stimulants late in the day, especially if you’re sensitive.
- Stick to a consistent sleep schedule and create a calming bedtime routine.
- Monitor symptoms. If insomnia continues beyond a few weeks, let your provider know.
Your doctor might:
- Adjust your dosage
- Recommend switching to a different antidepressant
- Suggest additional support like CBT-I (Cognitive Behavioral Therapy for Insomnia)
When Should You See a Doctor?
If you’re experiencing:
- Severe insomnia
- Fatigue during the day
- Mood changes or anxiety worsening due to poor sleep
Then it’s time to speak with your healthcare provider. Don’t stop taking Wellbutrin without medical advice.
Final Thoughts
While Wellbutrin is an effective antidepressant for many people, it can cause side effects like insomnia. The good news is that this issue is often manageable with proper timing, monitoring, and support from your healthcare team.
